Discover the top 10 at-home Botox-in-a-Bottle skincare picks, chosen by dermatologists for smoothing fine lines and elevating your daily routine. These max-strength treatments, creams, and serums are designed to deliver noticeable results without injections. Whether you are new to anti aging skincare or seeking an expert approved upgrade, this dermatologist curated guide highlights safe, effective options you can add to your regimen today. Healthy living starts here — explore our curated wellness collection. 1. Peptide serum with a Botox-like peptide - what it is: a concentrated peptide serum that targets expression lines - why it helps: may soften dynamic lines and improve skin texture with nightly use - key ingredients: botox-like peptide, hyaluronic acid - how to use: apply a few drops to clean skin before moisturizer 2. Retinol night cream - what it is: a max strength retinoid night cream - why it helps: stimulates collagen and speeds cell turnover to reduce fine lines - key ingredients: retinol or retinaldehyde - how to use: start slowly 2–3 nights per week, then increase as tolerated 3. Hyaluronic acid serum with ceramides - what it is: plumping hyaluronic acid formula with barrier supporting ceramides - why it helps: hydrates deeply to soften lines and improve texture - key ingredients: hyaluronic acid, ceramides - how to use: apply to damp skin for best absorption 4. Multi peptide day cream with SPF - what it is: daytime cream combining several anti wrinkle peptides - why it helps: provides ongoing smoothing plus sun protection - key ingredients: multiple peptides, broad spectrum SPF - how to use: apply in the morning after serum 5. Retinoid complex night treatment - what it is: gentle, time released retinoid blend - why it helps: supports collagen and skin renewal while minimizing irritation - key ingredients: retinoid blend, soothing botanicals - how to use: use on non consecutive evenings until tolerance improves 6. Vitamin C brightening serum - what it is: antioxidant vitamin C formula - why it helps: reduces dullness, boosts radiance, supports collagen - key ingredients: stabilized ascorbic acid - how to use: apply in the morning before sunscreen 7. Niacinamide peptide serum - what it is: brightening and texture improving serum with peptides - why it helps: evens skin tone and smooths rough patches - key ingredients: niacinamide, peptides - how to use: apply twice daily after cleansing 8. Eye cream with peptides and caffeine - what it is: targeted eye treatment for fine lines and puffiness - why it helps: reduces the look of crow's feet and refreshes tired eyes - key ingredients: peptides, caffeine - how to use: dab around orbital bone morning and night 9. Overnight firming treatment with peptides - what it is: deep overnight peptide treatment - why it helps: supports firmness and reduces wrinkles as you sleep - key ingredients: peptides, soothing hydrators - how to use: apply as the last step before bed 10. Deep absorption firming moisturizer - what it is: rich cream with peptides for long lasting smoothing - why it helps: nourishes and tightens without heaviness - key ingredients: peptides, emollients - how to use: apply day and night as needed Healthy living starts here — explore our curated wellness collection.